By David T. Curiel, Joanne T. Douglas

ISBN-10: 1588292134

ISBN-13: 9781588292131

ISBN-10: 1592597858

ISBN-13: 9781592597857

An entire creation and consultant to the newest advancements in melanoma gene therapy-from bench to bedside. The authors comprehensively assessment the anticancer genes and gene supply equipment at the moment to be had for melanoma gene treatment, together with the move of genetic fabric into the melanoma cells, stimulation of the immune approach to acknowledge and do away with melanoma cells, and the concentrating on of the nonmalignant stromal cells that aid their development. additionally they completely study the benefits and boundaries of different remedies and aspect thoughts to beat stumbling blocks to their medical implementation. themes of particular curiosity comprise vector-targeting strategies, the teachings realized to this point from medical trials of melanoma gene treatment, and the regulatory instructions for destiny trials. Noninvasive recommendations to watch the level of gene move and affliction regression throughout the process remedy also are mentioned.

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Grimm, E. , Zhang, W. , Owen-Schaub, L. , and Roth, J. A. (1994) Induction of chemosensitivity in human cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Surg. Forum 45, 524–526. 66. Nguyen, D. , Spitz, F. , Cristiano, R. , and Roth, J. A. (1996) Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J. Thorac. Cardiovasc. Surg. 112, 1372–1377. 67. , et al. (1996) The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers.

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19, 460a. 59. , and Oren, M. (1991) Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature 352, 345–347. 60. , Magnusson, K. , and Klein, G. (1993) Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53. Oncogene 8, 1495–1500. 61. , and Costa, J. (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA 89, 4495–4499. 62. Dewey, W. , Ling, C. , and Meyn, R. E.

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Cancer Gene Therapy by David T. Curiel, Joanne T. Douglas


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