By Richard, M.D. Pazdur
Written by way of one hundred ten of the nation's prime oncologists, melanoma administration: A Multidisciplinary method is the recipient of unanimous compliment from over 3,500 melanoma experts world wide. A most efficient resource of melanoma details from levels 0-IV, this textbook information the very most up-to-date screening, diagnostic, staging, remedy, and results for common sufferer administration. part heads include:* ideas of multidisciplinary treatments* Head and neck cancers* Lung melanoma* Breast melanoma* Gastrointestinal cancers* Genitourinary malignancies* Gynecologic malignancies* epidermis cancers* Sarcomas* Miscellaneous sturdy tumors* Hematologic malignancies* Palliative/supportive care* problems* Miscellaneous* info on newly authorized FDA medications* Appendices and index
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This quantity is a part of a publication sequence that was once first released in 10-volumes through Kluwer in 1989 below the sequence editorship of Professor Hans E. Kaiser, D. Sc. , former Professor of Pathology on the college of medication, collage of Maryland at Baltimore, MD, united states in addition to different leaders within the box of melanoma.
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Extra resources for Cancer Management: A Multidisciplinary Approach: Medical, Surgical and Radiation Oncology
However, in recent years, the incidence appears to have declined among white and black males. HEAD AND NECK TUMORS 39 HEAD AND NECK The anatomy of the head and neck is complex and is divided into sites and subsites (Figure 1). Tumors of each site have a unique epidemiology, anatomy, natural history, and therapeutic approach. This chapter will review these lesions as a group and then individually by anatomic site. Among blacks, head and neck cancer is associated with lower survival for similar tumor stages.
Alkylating agents depend on cell proliferation for activity but are not cell-cyclephase–specific. A fixed percentage of cells are killed at a given dose. Tumor resistance probably occurs through efficient glutathione conjugation or by enhanced DNA repair mechanisms. Alkylating agents are classified according to their chemical structures and mechanisms of covalent bonding; this drug class includes the nitrogen mustards, nitrosoureas, and platinum complexes, among other agents (see Table 5). Nitrogen mustards The nitrogen mustards, which include such drugs as mechlorethamine (Mustargen), cyclophosphamide, ifosfamide (Ifex), and chlorambucil (Leukeran), are powerful local vesicants; as such, they can cause problems ranging from local tissue necrosis, to pulmonary fibrosis, to hemorrhagic cystitis.
In countries with a high incidence of oral cavity cancer, such as India, screening may be helpful and is currently under evaluation. DIAGNOSIS The need for expeditious diagnosis of head and neck cancer and referral to a skilled head and neck specialist cannot be overemphasized, as early diagnosis can lead to a reduction in mortality. 5 health-care visits. These visits provide an opportunity to evaluate patients’ symptoms and underscore the important role of dentists and primary care physicians in the early diagnosis of head and neck cancer.
Cancer Management: A Multidisciplinary Approach: Medical, Surgical and Radiation Oncology by Richard, M.D. Pazdur
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