By Donald W. Seldin, Gerhard H. Giebisch

ISBN-10: 0126356904

ISBN-13: 9780126356908

The single entire paintings to hide all features of diuretic brokers, the booklet discusses the pharmacology and toxicology of diuretic brokers in addition to the physiological results. specialists within the box current the rules and experimental methods for the examine of interactions among pharmacologic compounds relating to particular goal organs. Diuretic Agents includes details at the mechanisms of motion and alertness of diuretics, and information FDA rules and pharmaceutical directions.

Key Features
* Written through specialists within the field
* Covers all facets of diuretic agents
* comprises details at the mechanisms of motion and alertness of diuretics

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Extra info for Diuretic Agents: Clinical Physiology and Pharmacology

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H o w e v e r , if in a d d i t i o n , an apical m e m b r a n e C1/base e x c h a n g e r o p e r a t e s at a rate e q u a l to t h a t of the apical m e m b r a n e N a / H a n t i p o r t e r the n e t r e s u l t is NaC1 a b s o r p t i o n . S e c r e t i o n of H § a n d a n e g a t i v e l y c h a r g e d base ( B - ) at e q u a l rates leads to g e n e r a t i o n of the n e u t r a l acid, HB, w h i c h is l i p o p h i l i c a n d is t h o u g h t to recycle across the apical m e m b r a n e .

It was the relationship between organic chemists and the new breed of renal physiologists that was to provide the basis for the development of new and effective diuretics. Diuretics, in turn, were to provide, initially renal physiologists and subsequently renal biochemists, powerful probes with which to explore renal function. DIGITALIS The most important contribution of herbal medicine to the materia medica of the 18th century was foxglove. The purple foxglove, a rather common plant growing throughout the greater part of Europe, is not mentioned by the founding father of herbal medicine, Dioscorides, or in any of the ancient herbals.

Small, had made it a practice to give his advice to the poor during one hour in the day. This practice, which I continued until we had an Hospital opened for the reception of the sick poor, gave me the opportunity of putting my ideas into execution in a variety of cases; for the number of poor who thus applied for advice, amounted to between two and three thousand annually. I soon found the Foxglove to be a very powerful diuretic. At the time dropsy was considered a primary disease, the distinction between cardiac and renal dropsy had to await the analysis in 1813 by John Blackall ( 1 7 7 1 - 1 8 6 0 ) of the nature and cure of his dropsical cases and in 1827 the report of Richard Bright ( 1 7 8 9 - 1 8 5 8 ) of his own medical cases.

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Diuretic Agents: Clinical Physiology and Pharmacology by Donald W. Seldin, Gerhard H. Giebisch


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