By Mary A. B. Brazier

ISBN-10: 0121286509

ISBN-13: 9780121286507

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Extra info for Epilepsy: Its Phenomena in Man

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In one cell we found evidence of a probably + abnormally slow removal of extracellular K , but the technical and sampling problems made the general study inconclusive. Furthermore, after completing the study we realized that our method could only test excitability in those regions where the spike undershoot was occurring; consequently, there has been as yet no test of excitability changes as a consequence of + a K buildup along presynaptic terminals or upon relatively distant dendrites. In view of the large "dendritic" potentials comprising the primary surface negative part of the electroencephalogram ( E E G ) spike, the input stage of the cell would seem to be the most likely place to look for the hypothesized abnormality to appear.

IIIIIIIII 100 μ ν I 1s. /WWY Figure 4. Effects of photic stimulation at various frequencies in BON . . Chan. Paroxysmal features appear for many stimulation frequencies but polyspike-and-wave discharges, accompanied by myoclonus (star), occur only in response to frequencies close to 15 cps. ILS—intermittent light stimulus. waves numbered V and VI according to the terminology of Gastaut and Regis ( 2 1 ) ; for example, even as high as 200-250 μ\ for wave V I ] . The latencies of the late waves were shorter than in normal subjects ( 100 msec as against 130 msec for wave V, and 170 msec against 200 msec for wave V I ) .

This consisted of disconnection of the insertion of all the periocular and periorbital musculature. This was performed after premedication with atropine and either under general anesthesia with pentobarbital or after Fluothane anesthesia, intubation, artificial respiration, Flaxedil immobilization, and additional local anesthesia. The technique of stimulation and implantation has been reported by Dimov and co-workers ( 1 3 ) . Study of the Animal's Photosensitivity. When the animals were tested after operation on the facial nerve and before any interference with the periocular musculature they still showed the same degree of photosensitivity, although as we mentioned above the clinical signs were somewhat different from those seen in intact animals (38, 4 1 ) .

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