By Robert Coleman, David Fox, Geny Groothius, Colin Garner, Ellen Berg, Katherine Tsaioun, Gerry Thomas, Martin Brunner, Kelly BeruBe, James Hickman, David Bunton

ISBN-10: 030916124X

ISBN-13: 9780309161244

ISBN-10: 0309161258

ISBN-13: 9780309161251

ISBN-10: 1283376199

ISBN-13: 9781283376198

ISBN-10: 1782620133

ISBN-13: 9781782620136

ISBN-10: 1849738254

ISBN-13: 9781849738255

This e-book will offer a close background and dialogue of using human tissues in its place to animal-based trying out for assessing the efficacy and defense of recent medicinal drugs. starting by means of offering the background and historical past of animal-based trying out, this article then describes intimately the problems when it comes to entry to human cells and tissue and the principles and rules governing their use. The publication comprises chapters on tissue slices, tradition, assays, microfluidics and body-on-a-chip know-how, in addition to chapters on rising applied sciences and methods similar to engineered organs. each one bankruptcy comprehensively covers a strategy, from its utilisation and technique to the possibilities and obstacles of the strategy. Written and edited by means of world wide specialists in the box, this e-book could be a necessary textual content for biochemists and researchers operating in translational medication in either and academia

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This publication will supply a close heritage and dialogue of using human tissues as a substitute to animal-based checking out for assessing the efficacy and protection of latest medications. starting by way of offering the heritage and historical past of animal-based trying out, this article then describes intimately the problems in relation to entry to human cells and tissue and the foundations and laws governing their use.

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Schneiderat, Adv. Exp. Med. , 2010, 686, 105. 48. M. Perera, J. R. Petrie, C. Hillier, M. Small, N. Sattar, J. M. Connell and M. A. Lumsden, Hum. , 2002, 17, 497. 49. B. H. C. Stricker, Br. Med. , 1992, 305, 118. CHAPTER 3 Translational Research in Pharmacology and Toxicology Using Precision-Cut Tissue Slices G. M. M. GROOTHUIS*a, A. CASINIa, H. MEURSb, AND P. OLINGAc a Division of Pharmacokinetics, Toxicology & Targeting, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, the Netherlands; bDivision of Molecular Pharmacology, Department of Pharmacy, University of Groningen, A.

L. E. Powers, K. S. Gronowski and A. M. Gronowski, Clin. , 2010, 56, 1675. 6. L. Andrews, The Havasupai Case: Research without Patient Consent [online]. html (accessed 8 August 2014). 7. M. G. Hansson, J. Dillner, C. R. , 2006, 7, 266. 8. K. Hoeyer, Public Health Genomics, 2010, 13, 345. 9. Human Tissue Authority. Consent exemptions from the Human Tissue Act 2004 [online]. cfm (accessed 11 September 2014). 10. Integrated Research Application System. Guidance document for researchers [online]. myresearchproject.

Protoc. 3. 20. F. Marceau, D. deBlois, E. Petitclerc, L. Levesque, G. Drapeau, R. Audet, D. Godin, J. F. LarrivĀ“ ee, S. Houle, T. Sabourin, J. P. Fortin, G. Morissette, L. Gera, M. T. Bawolak, G. A. Koumbadinga and J. Bouthillier, Int. , 2010, 10, 1344. 21. E. Moss, S. Lynagh, D. Smith, S. Kelly, A. McDaid and D. Bunton, J. Pharmacol. Toxicol. Methods, 2010, 62, 40. 22. Z. Zhou, P. Subramanian, G. Sevilmis, B. Globke, O. Soehnlein, E. Karshovska, R. Megens, K. Heyll, J. Chun, J. S. Saulnier-Blache, M.

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Human-based Systems for Translational Research by Robert Coleman, David Fox, Geny Groothius, Colin Garner, Ellen Berg, Katherine Tsaioun, Gerry Thomas, Martin Brunner, Kelly BeruBe, James Hickman, David Bunton


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