By Robert Coleman, David Fox, Geny Groothius, Colin Garner, Ellen Berg, Katherine Tsaioun, Gerry Thomas, Martin Brunner, Kelly BeruBe, James Hickman, David Bunton
This e-book will offer a close background and dialogue of using human tissues in its place to animal-based trying out for assessing the efficacy and defense of recent medicinal drugs. starting by means of offering the background and historical past of animal-based trying out, this article then describes intimately the problems when it comes to entry to human cells and tissue and the principles and rules governing their use. The publication comprises chapters on tissue slices, tradition, assays, microfluidics and body-on-a-chip know-how, in addition to chapters on rising applied sciences and methods similar to engineered organs. each one bankruptcy comprehensively covers a strategy, from its utilisation and technique to the possibilities and obstacles of the strategy. Written and edited by means of world wide specialists in the box, this e-book could be a necessary textual content for biochemists and researchers operating in translational medication in either and academia
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Extra resources for Human-based Systems for Translational Research
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L. E. Powers, K. S. Gronowski and A. M. Gronowski, Clin. , 2010, 56, 1675. 6. L. Andrews, The Havasupai Case: Research without Patient Consent [online]. html (accessed 8 August 2014). 7. M. G. Hansson, J. Dillner, C. R. , 2006, 7, 266. 8. K. Hoeyer, Public Health Genomics, 2010, 13, 345. 9. Human Tissue Authority. Consent exemptions from the Human Tissue Act 2004 [online]. cfm (accessed 11 September 2014). 10. Integrated Research Application System. Guidance document for researchers [online]. myresearchproject.
Protoc. 3. 20. F. Marceau, D. deBlois, E. Petitclerc, L. Levesque, G. Drapeau, R. Audet, D. Godin, J. F. Larriv´ ee, S. Houle, T. Sabourin, J. P. Fortin, G. Morissette, L. Gera, M. T. Bawolak, G. A. Koumbadinga and J. Bouthillier, Int. , 2010, 10, 1344. 21. E. Moss, S. Lynagh, D. Smith, S. Kelly, A. McDaid and D. Bunton, J. Pharmacol. Toxicol. Methods, 2010, 62, 40. 22. Z. Zhou, P. Subramanian, G. Sevilmis, B. Globke, O. Soehnlein, E. Karshovska, R. Megens, K. Heyll, J. Chun, J. S. Saulnier-Blache, M.
Human-based Systems for Translational Research by Robert Coleman, David Fox, Geny Groothius, Colin Garner, Ellen Berg, Katherine Tsaioun, Gerry Thomas, Martin Brunner, Kelly BeruBe, James Hickman, David Bunton
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