By M. Demerec (Eds.)

ISBN-10: 0120176033

ISBN-13: 9780120176038

This quantity in a chain on genetics, emphasizes the variety of genetic stories. Articles hide the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable components and the dropophila gene zeste.

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12. Succinic Acid . . . . . . . . . . . 13. Nucleic Acid Constituents . . . . . . . . a . Purines b . Pyrimidines . . . . . . . . . . . I V. The Gene as a Unit of Function . . . . . . . . 1. The One Gene-One Enzyme Hypothesis . . . . . . 2. The Selection Problem . . . . . . . . . 3. Gene Action . . . . . . . . . . . . V References . . . . . . . . . . . . . . * Page 33 35 . 35 . 39 . . ....................

Nuclear element (n) aa in 24-hour or older cultures. 36. E. coli. Same as Fig. 34. Nuclear element ( n ) dividing. 38. Bacterial cell in intestine of tadpole. Smear fixed with chloroform, then Feulgen reaction. Nuclear axial thread, n. 39. E. coli, strain B M . 24-hour culture in aerated nutrient broth at 37°C. Giemsa staining. Various aspects of cells. Fro. 40. Same as Fig. 39; division figures of nuclear elements. 41-43. E. coli, strain B/r. 42-hour culture in nonaerated nutrient broth at 37°C.

Biochemists are well aware of these and related problems and have therefore devised techniques for experimenting a t all levels of organization from the whole organism down to homogeneous solutions, so that one is not required to remain satisfied with the results obtained by any single method. Experiments on the intact organism are theoretically the least objectionable, but, until recently have also been the least productive of information on the mechanisms of biochemical transformations. The use of isotopic tracers and of single-gene mutations now provide two powerful methods for the study of intermediary metabolism in the whole organism.

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Advances in Genetics by M. Demerec (Eds.)

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